Description

4-Chloro-5-Methyl-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine is a high-value, organosilicon-protected heterocyclic building block essential for advanced organic synthesis. This compound matters because it provides a versatile and reactive scaffold for constructing complex molecules, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other small-molecule drug candidates targeting various therapeutic areas.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science: Serves as a building block for organic semiconductors, light-emitting diodes (OLEDs), and other functional electronic materials.
• Chemical Biology: Employed in the design and synthesis of molecular probes and tool compounds for studying biological pathways.
• Cross-Coupling Reactions: The chloro and silyl groups offer orthogonal reactivity for sequential functionalization via Suzuki, Stille, or other metal-catalyzed cross-coupling methodologies.
• Directed C-H Functionalization: The pyrrolopyridine core can act as a directing group for regioselective C-H bond activation and derivatization.

Basic Information

Product Name	4-Chloro-5-Methyl-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	942920-17-4
Molecular Formula	C18H29ClN2Si
Molecular Weight	336.97 g/mol
Synonyms	1H-Pyrrolo[2,3-b]pyridine, 4-chloro-5-methyl-1-[(1,1-dimethylethyl)dimethylsilyl]-; 4-Chloro-5-methyl-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; 1-Triisopropylsilyl-4-chloro-5-methyl-1H-pyrrolo[2,3-b]pyridine; TIPS-4-Chloro-5-methyl-1H-pyrrolo[2,3-b]pyridine; 4-Chloro-5-methyl-1-(triisopropylsilyl)-7-azaindole; 942920-17-4
EINECS	Contact for details

Quality Control

Our 4-Chloro-5-Methyl-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent chemical identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.