Description

Gandotinib CAS NO 942577-31-3 is a potent and selective small-molecule inhibitor targeting the JAK/STAT signaling pathway. This compound is of significant value in pharmaceutical research and development for its potential therapeutic applications in oncology and inflammatory diseases. It is primarily needed by research institutions, biotechnology companies, and pharmaceutical manufacturers engaged in the discovery and synthesis of novel kinase-targeted therapies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced active pharmaceutical ingredients (APIs) targeting kinase pathways.
• Biochemical Research: Used as a reference standard and tool compound in enzymatic assays and cellular studies to investigate JAK/STAT signaling mechanisms.
• Preclinical Development: Employed in the formulation and testing stages for developing new oncology and immunology drug candidates.
• High-Throughput Screening (HTS): Serves as a control or lead compound in screening libraries to identify and validate new drug targets.
• Academic Research: Utilized in university and institutional labs for fundamental research into cell proliferation, apoptosis, and immune response regulation.

Basic Information

Product Name	Gandotinib
CAS No.	942577-31-3
Molecular Formula	C₂₃H₂₅N₅O₂
Molecular Weight	403.48 g/mol
Synonyms	LY2784544; Gandotinib (LY2784544); 4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine; N-(3-(tert-Butyl)-1-phenyl-1H-pyrazol-5-yl)-3-(5-fluoro-2-methoxypyridin-3-yl)-1H-pyrazolo[3,4-b]pyridin-5-amine; JAK2 Inhibitor LY2784544; (S)-Gandotinib; UNII-9Q0B6S6F6I
EINECS	Contact for details

Quality Control

Our Gandotinib is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.