Description

(S)-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)-4-Azidobutanoic Acid is a high-purity, non-natural amino acid derivative featuring a strategically placed azido functional group. This compound is a critical building block in advanced bioconjugation and peptide synthesis, enabling the site-specific introduction of bioorthogonal handles via click chemistry. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and the creation of antibody-drug conjugates (ADCs) and other complex biomolecules.

Application

• Peptide Synthesis: Used as a protected, azide-functionalized amino acid building block in Solid-Phase Peptide Synthesis (SPPS) for introducing clickable sites into peptide sequences.
• Bioconjugation & ADC Development: Enables site-specific labeling and conjugation of proteins, antibodies, and other biomolecules through strain-promoted azide-alkyne cycloaddition (SPAAC) or copper-catalyzed click reactions.
• Chemical Biology & Proteomics: Serves as a metabolic labeling precursor or a tool for post-translational modification studies to investigate protein function and interactions.
• Material Science & Polymer Chemistry: Incorporated into polymers or surfaces to create functional, bio-active materials with tailored properties for biomedical applications.
• Ligand & Probe Synthesis: A key intermediate for synthesizing targeted imaging probes, diagnostic agents, and bioactive small molecules.

Basic Information

Product Name	(S)-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)-4-Azidobutanoic Acid
CAS No.	942518-20-9
Molecular Formula	C19H18N4O4
Molecular Weight	366.37 g/mol
Synonyms	Fmoc-L-Azidohomoalanine; Fmoc-Aha-OH; N-α-Fmoc-L-2,4-diaminobutanoic acid 4-azide; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-azidobutanoic acid; Fmoc-L-4-azidohomoalanine; Fmoc-L-2-Amino-4-azidobutanoic acid; Azidohomoalanine-Fmoc; AHA(Fmoc)-OH
EINECS	Contact for details

Quality Control

Our (S)-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)-4-Azidobutanoic Acid is manufactured under strict quality control protocols to ensure high chemical purity and consistency, suitable for sensitive research and development applications. Each batch is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided to guarantee compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, store desiccated at 2-8°C. Allow the container to reach room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.