Description

1H-Benzimidazole-1-Carboxylic Acid, 4-(Bromomethyl)-6-Chloro-, 1,1-Dimethylethyl Ester is a high-value, multi-functional chemical intermediate featuring a reactive bromomethyl group and a protected carboxylic acid. This compound is specifically engineered for advanced synthetic chemistry, offering a versatile scaffold for constructing complex molecules with precision. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialized organic materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel benzimidazole-based drug candidates, including potential kinase inhibitors and antiviral agents.
• Agrochemical Research: Used in the development of new fungicides and herbicides, leveraging its halogenated structure for bioactivity.
• Organic Synthesis: Serves as a versatile precursor for further functionalization via nucleophilic substitution of the bromomethyl group or deprotection of the tert-butyl ester.
• Material Science: Employed in the research and development of advanced organic polymers and ligands for catalytic systems.
• Chemical Biology: Utilized as a probe or linker molecule in bioconjugation and proteomics research due to its reactive handles.

Basic Information

Item	Details
Product Name	1H-Benzimidazole-1-Carboxylic Acid, 4-(Bromomethyl)-6-Chloro-, 1,1-Dimethylethyl Ester
CAS No.	942317-90-0
Molecular Formula	C14H16BrClN2O2
Molecular Weight	359.65 g/mol
Synonyms	tert-Butyl 4-(bromomethyl)-6-chloro-1H-benzimidazole-1-carboxylate; 6-Chloro-4-(bromomethyl)-1H-benzimidazole-1-carboxylic acid 1,1-dimethylethyl ester; 4-(Bromomethyl)-6-chloro-1-((tert-butoxy)carbonyl)-1H-benzimidazole; 1-(tert-Butoxycarbonyl)-4-(bromomethyl)-6-chlorobenzimidazole; Boc-4-bromomethyl-6-chloro-benzimidazole; 942317-90-0; 4-Bromomethyl-6-chloro-1H-benzimidazole-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of 1H-Benzimidazole-1-Carboxylic Acid, 4-(Bromomethyl)-6-Chloro-, 1,1-Dimethylethyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All material is released with a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support development and commercial projects requiring material that meets ICH guidelines for impurities and can provide custom synthesis under GMP conditions for advanced clinical stage applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area%)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.