Description

1-Boc-3-Hydroxy-3-Pyrrolidinedicarboxylic Acid Methyl Ester is a high-purity, protected pyrrolidine derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a versatile, functionalized scaffold for constructing complex molecules with precise stereochemistry. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, including protease inhibitors and other biologically active molecules.
• Peptidomimetic Research: Used to construct proline-like structures and conformationally constrained peptide analogs in medicinal chemistry.
• Agrochemical Synthesis: Serves as a building block for developing novel pesticides and herbicides with specific chiral centers.
• Asymmetric Catalysis Ligand Precursor: A starting material for the synthesis of chiral ligands used in asymmetric hydrogenation and other catalytic transformations.
• Chemical Biology Probes: Utilized in the development of molecular probes to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A fundamental component for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing specialized fine chemicals.

Basic Information

Product Name	1-Boc-3-Hydroxy-3-Pyrrolidinedicarboxylic Acid Methyl Ester
CAS No.	942190-61-6
Molecular Formula	C13H21NO7
Molecular Weight	303.31 g/mol
Synonyms	3-Hydroxy-1-[(2-methyl-2-propanyl)oxycarbonyl]-3-pyrrolidinedicarboxylic Acid Dimethyl Ester; 1-(tert-Butoxycarbonyl)-3-hydroxy-3-pyrrolidinedicarboxylic Acid Dimethyl Ester; 1-Boc-3-hydroxy-3-pyrrolidinedicarboxylic Acid Dimethyl Ester; Dimethyl 1-Boc-3-hydroxypyrrolidine-3,3-dicarboxylate; 1-Boc-3-hydroxy-3-pyrrolidinecarboxylic Acid Dimethyl Ester; tert-Butyl 3-hydroxy-3-(methoxycarbonyl)-4-(methoxycarbonylmethyl)-2-pyrrolidinecarboxylate
EINECS	Contact for details

Quality Control

Our 1-Boc-3-Hydroxy-3-Pyrrolidinedicarboxylic Acid Methyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality management system is designed to meet the stringent requirements of pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.