Description

1-tert-Butyl 3-Methyl 3-Aminopyrrolidine-1,3-Dicarboxylate is a high-purity, protected aminopyrrolidine derivative serving as a critical chiral building block and advanced pharmaceutical intermediate. This compound is essential for the synthesis of complex molecules, offering a versatile scaffold for introducing stereochemistry and functional groups in medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers developing active pharmaceutical ingredients (APIs), particularly in the areas of central nervous system (CNS) therapeutics and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile building block for constructing complex heterocyclic compounds and probing structure-activity relationships (SAR).
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric reactions to introduce stereogenic centers with high enantiomeric purity.
• Protease Inhibitor Development: Serves as a core structural element in the design and synthesis of inhibitors for various protease enzymes.
• Chemical Biology & Probe Development: Utilized to create molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied for custom synthesis projects requiring high-fidelity, protected amine intermediates.

Basic Information

Product Name	1-tert-Butyl 3-Methyl 3-Aminopyrrolidine-1,3-Dicarboxylate
CAS No.	942190-47-8
Molecular Formula	C11H20N2O4
Molecular Weight	244.29 g/mol
Synonyms	3-Amino-1-(tert-butoxycarbonyl)-3-methylpyrrolidine-3-carboxylic acid methyl ester; Methyl 3-amino-1-[(2-methylpropan-2-yl)oxycarbonyl]-3-methylpyrrolidine-3-carboxylate; 1-Boc-3-methyl-3-aminopyrrolidine-3-carboxylic acid methyl ester; tert-Butyl 3-(methoxycarbonyl)-3-methyl-3-aminopyrrolidine-1-carboxylate; 3-Amino-1-Boc-3-methylpyrrolidine-3-carboxylic acid methyl ester; Boc-3-amino-3-methyl-pyrrolidine-3-carboxylic acid methyl ester; Protected 3-Aminopyrrolidine Derivative
EINECS	Contact for details

Quality Control

Our 1-tert-Butyl 3-Methyl 3-Aminopyrrolidine-1,3-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.