Description

Ruxolitinib is a potent and selective Janus kinase (JAK) 1 and JAK 2 inhibitor, a key compound in pharmaceutical research and development. Its primary value lies in its targeted mechanism of action, which is critical for developing therapies for myeloproliferative neoplasms and other inflammatory conditions. This high-purity intermediate is essential for pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in the synthesis of novel therapeutics and advanced clinical studies.

Application

• Pharmaceutical Active Pharmaceutical Ingredient (API) Synthesis: Primary use as a critical intermediate in the commercial manufacturing of Ruxolitinib API.
• Research and Development: Serves as a key reference standard and building block in medicinal chemistry for developing new JAK inhibitor analogs.
• Preclinical and Clinical Studies: Used in formulating drug products for toxicity, pharmacokinetic, and efficacy studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production.
• Biochemical Research: Utilized as a selective tool compound to study JAK-STAT signaling pathways in cellular and molecular biology.

Basic Information

Product Name	Ruxolitinib
CAS No.	941678-49-5
Molecular Formula	C17H18N6
Molecular Weight	306.36 g/mol
Synonyms	INCB018424; (R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile; Jakafi (trade name); Jakavi (trade name); Ruxolitinib phosphate; Cyclopentylpropanenitrile, 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-, (3R)-; UNII-82S8X8XX8H
EINECS	Contact for details

Quality Control

Our Ruxolitinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods (IR, NMR, MS), to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.