Description

2’-Deoxy-2’-Fluoro-4’-Thio-β-D-Arabinouridine is a high-purity, modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound is a key synthetic intermediate and building block for the creation of novel antiviral and anticancer therapeutics, particularly those targeting RNA viruses. It is essential for research institutions, pharmaceutical companies, and CDMOs engaged in the synthesis of next-generation nucleoside-based drugs, where its unique fluorinated and thio-modified sugar moiety imparts critical metabolic stability and binding affinity.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel antiviral and anticancer prodrugs.
• Antiviral Drug Research: Used in the development of therapeutics targeting RNA viruses, including hepatitis C virus (HCV) and other emerging pathogens.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies related to nucleoside metabolism and polymerase function.
• Preclinical Development: Used in the synthesis of compounds for in vitro and in vivo pharmacological evaluation.
• Process Chemistry: Serves as a starting material for scaling up the synthesis of active pharmaceutical ingredients (APIs) under GMP conditions.

Basic Information

Item	Details
Product Name	2’-Deoxy-2’-Fluoro-4’-Thio-β-D-Arabinouridine
CAS No.	941610-00-0
Molecular Formula	C9H11FN2O4S
Molecular Weight	262.26 g/mol
Synonyms	4'-Thio-2'-deoxy-2'-fluoro-β-D-arabinouridine; 2'-Deoxy-2'-fluoro-4'-thio-β-D-arabinofuranosyluracil; 2'-F-4'-S-β-D-arabinoU; 4'-Thio-FMAU; 941610-00-0; 2'-Fluoro-2'-deoxy-4'-thio-arabinouridine; β-2'-F-4'-S-arabino-Urd
EINECS	Contact for details

Quality Control

Every batch of 2’-Deoxy-2’-Fluoro-4’-Thio-β-D-Arabinouridine is manufactured and tested under strict quality management systems to ensure it meets the high-purity standards required for pharmaceutical research. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all specification results. We support development from research to commercial scale with consistent quality and full regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.