Description

1H-Imidazole-4-Carbonyl Chloride, 5-Amino- is a high-value, multi-functional chemical building block characterized by its reactive acid chloride group and primary amine functionality. This compound is essential for the synthesis of complex heterocyclic molecules, enabling the introduction of the imidazole pharmacophore into target structures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for constructing imidazole-based drug candidates, including kinase inhibitors, antifungal agents, and antiviral compounds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Peptide Mimetics & Bioconjugation: The acyl chloride group facilitates efficient amide bond formation for creating peptide analogs or conjugating molecules to biological carriers.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and functional materials.
• Ligand Synthesis for Catalysis: Employed in the preparation of complex nitrogen-containing ligands for metal-catalyzed reactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring precise molecular architecture.

Basic Information

Product Name	1H-Imidazole-4-Carbonyl Chloride, 5-Amino-
CAS No.	938443-47-1
Molecular Formula	C4H4ClN3O
Molecular Weight	145.55 g/mol
Synonyms	5-Amino-1H-imidazole-4-carbonyl chloride; 5-Aminoimidazole-4-carbonyl chloride; 4-(Chlorocarbonyl)-1H-imidazol-5-amine; 5-Amino-1H-imidazole-4-carboxylic acid chloride; 1H-Imidazole-4-carbonyl chloride, 5-amino-; 5-Amino-1H-imidazole-4-carboxyl chloride; 938443-47-1; 5-Aminoimidazole-4-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our 1H-Imidazole-4-Carbonyl Chloride, 5-Amino- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.