Description

Pyrazolo[1,5-A]Pyrimidine-3-Carbonyl Chloride is a high-value, reactive chemical intermediate characterized by its versatile carbonyl chloride functional group. This compound is critical for the synthesis of complex molecules, enabling the introduction of the pyrazolopyrimidine pharmacophore into target structures. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients, particularly kinase inhibitors and other biologically relevant heterocycles.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of kinase inhibitors, anticancer agents, and other therapeutic small molecules.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and plant growth regulators containing the pyrazolopyrimidine scaffold.
• Chemical Biology: Serves as a probe or linker precursor for protein labeling and bioconjugation studies due to its reactive acyl chloride group.
• Material Science: Potential monomer or cross-linking agent for creating specialized polymers with unique thermal or electronic properties.
• Academic & Contract Research: Essential reagent for methodological development and synthetic chemistry research in academic and CRO laboratories.

Basic Information

Product Name	Pyrazolo[1,5-A]Pyrimidine-3-Carbonyl Chloride
CAS No.	937602-40-9
Molecular Formula	C7H4ClN3O
Molecular Weight	181.58 g/mol
Synonyms	Pyrazolo[1,5-a]pyrimidine-3-carbonyl chloride; 3-Pyrazolo[1,5-a]pyrimidinecarbonyl chloride; 1H-Pyrazolo[1,5-a]pyrimidine-3-carbonyl chloride; Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid chloride; 937602-40-9; Pyrazolopyrimidine-3-carbonyl chloride
EINECS	Contact for details

Quality Control

Our Pyrazolo[1,5-A]Pyrimidine-3-Carbonyl Chloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and moisture-sensitive nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.