Description

Methanone, (5-Chloro-2-Fluorophenyl)[(3S)-3-[[4-(3-Cyclopropyl-3-Fluoro-1-Azetidinyl)-6-[(5-Methyl-1H-Pyrazol-3-Yl)Amino]-2-Pyrimidinyl]Oxy]-1-Pyrrolidinyl]- is a sophisticated, high-purity organic compound designed for advanced research and development applications. This molecule is of significant interest due to its complex heterocyclic structure, which incorporates multiple pharmacologically relevant motifs, including a fluorinated azetidine and a pyrimidine core. It serves as a critical building block or intermediate for medicinal chemists and process development scientists working in pharmaceutical discovery. Target users include R&D laboratories and fine chemical manufacturers focused on developing novel therapeutic agents, particularly in oncology and other disease areas.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs), especially kinase inhibitors.
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the efficient synthesis of complex drug candidates.
• Biochemical Research: May be utilized as a tool compound or ligand in biochemical assays to study specific enzyme targets and signaling pathways.
• Custom Synthesis: Acts as a starting material for the contract synthesis of specialized, non-commercial compounds for client-specific research projects.

Basic Information

Item	Details
Product Name	Methanone, (5-Chloro-2-Fluorophenyl)[(3S)-3-[[4-(3-Cyclopropyl-3-Fluoro-1-Azetidinyl)-6-[(5-Methyl-1H-Pyrazol-3-Yl)Amino]-2-Pyrimidinyl]Oxy]-1-Pyrrolidinyl]-
CAS No.	937276-52-3
Molecular Formula	C31H31ClF2N8O2
Molecular Weight	621.08 g/mol
Synonyms	(5-Chloro-2-fluorophenyl)[(3S)-3-[[4-(3-cyclopropyl-3-fluoro-1-azetidinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]oxy]-1-pyrrolidinyl]methanone; (S)-N-(5-Chloro-2-fluorophenyl)-1-(3-((4-(3-cyclopropyl-3-fluoroazetidin-1-yl)-6-((5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)oxy)pyrrolidin-1-yl)methanone; AZD-9291 Intermediate; Osimertinib Intermediate; Tagrisso Intermediate; (S)-Osimertinib Intermediate; EGFR Inhibitor Intermediate; 937276-52-3
EINECS	Contact for details

Quality Control

Our production of Methanone, (5-Chloro-2-Fluorophenyl)[(3S)-3-[[4-(3-Cyclopropyl-3-Fluoro-1-Azetidinyl)-6-[(5-Methyl-1H-Pyrazol-3-Yl)Amino]-2-Pyrimidinyl]Oxy]-1-Pyrrolidinyl]- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive R&D applications. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Our quality systems are designed to support development work under cGMP guidelines where required, and we can provide material suitable for use in regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.