Description

Pacritinib CAS NO 937272-79-2 is a potent and selective small-molecule inhibitor of Janus kinase 2 (JAK2) and FMS-like tyrosine kinase 3 (FLT3). This compound is of significant interest for its targeted mechanism of action in disrupting key signaling pathways involved in cellular proliferation. It is primarily utilized by pharmaceutical research and development organizations engaged in oncology drug discovery and clinical development programs.

Application

• Oncology Research: A key investigational agent for the study and treatment of myeloproliferative neoplasms (MPNs), particularly myelofibrosis.
• Kinase Profiling Studies: Used as a selective tool compound in biochemical and cellular assays to understand JAK2 and FLT3 signaling pathways.
• Preclinical Development: Serves as an active pharmaceutical ingredient (API) in formulation studies for injectable or oral dosage forms.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Combination Therapy Research: Investigated in conjunction with other therapeutic agents to explore synergistic effects in hematological malignancies.

Basic Information

Product Name	Pacritinib
CAS No.	937272-79-2
Molecular Formula	C₂₈H₃₁N₇O
Molecular Weight	481.59 g/mol
Synonyms	SB1518; Pacritinib (SB1518); (1E)-1-{2,4-Dichloro-5-[(1-methyl-1H-pyrazol-5-yl)oxy]phenyl}-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-2-propen-1-one; UNII-4KZ47183Q4
EINECS	Contact for details

Quality Control

Our Pacritinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation by spectroscopic methods. We provide full traceability and Certificates of Analysis (COA) compliant with current industry standards for pharmaceutical intermediates and reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.