Description

2-Bromo-3,4-Difluoroacetophenone is a versatile and high-value halogenated aromatic ketone building block. This compound is critical for the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries for constructing novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing difluorophenyl and bromoacetyl motifs for targeted therapies.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the halogen and fluorine substitutions enhance biological activity and metabolic stability.
• Material Science Research: Serves as a building block for advanced organic materials, including liquid crystals and specialty polymers.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create more complex biaryl structures.
• Fluorinated Compound Libraries: Essential for medicinal chemistry programs focused on creating fluorinated compound libraries to explore structure-activity relationships (SAR).
• Chemical Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	2-Bromo-3,4-Difluoroacetophenone
CAS No.	936846-32-1
Molecular Formula	C8H5BrF2O
Molecular Weight	235.03 g/mol
Synonyms	1-(2-Bromo-3,4-difluorophenyl)ethan-1-one; 2'-Bromo-3',4'-difluoroacetophenone; 3',4'-Difluoro-2'-bromoacetophenone; α-Bromo-3,4-difluoroacetophenone; Ethanone, 1-(2-bromo-3,4-difluorophenyl)-; 2-Bromo-3,4-difluoroacetophenone; 936846-32-1; 2-Br-3,4-diF-acetophenone
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-3,4-Difluoroacetophenone is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements of research and process chemistry. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting purity, identity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Related Substances (HPLC)	Individual impurity ≤1.0%; Total impurities ≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.