Description

2'-Bromo-4'-Fluoroacetophenone is a versatile and high-purity halogenated acetophenone derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both bromine and fluorine substituents, makes it an exceptionally valuable intermediate for introducing specific functional groups into target molecules. This compound is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors for developing novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those requiring halogenated aromatic ketone motifs for bioactivity.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and pesticides, where the bromo and fluoro groups can enhance compound stability and efficacy.
• Liquid Crystal & OLED Material Research: Serves as a starting material for synthesizing fluorinated organic compounds used in electronic displays and advanced materials.
• Cross-Coupling Reactions: Acts as a valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to construct complex biaryl structures.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating novel chemical entities.
• Fine Chemical Production: Utilized in the multi-step synthesis of other high-value, specialty fine chemicals and flavors/fragrances intermediates.

Basic Information

Product Name	2'-Bromo-4'-Fluoroacetophenone
CAS No.	1006-39-9
Molecular Formula	C8H6BrFO
Molecular Weight	217.04 g/mol
Synonyms	1-(2-Bromo-4-fluorophenyl)ethanone; 2-Bromo-4-fluoroacetophenone; 2'-Bromo-4'-fluoroacetophenone; α-Bromo-4-fluoroacetophenone; 1-Acetyl-2-bromo-4-fluorobenzene; 2-Bromo-4'-fluoroacetophenone; 4-Fluoro-2-bromoacetophenone; (2-Bromo-4-fluorophenyl)methyl ketone
EINECS	Contact for details

Quality Control

Our 2'-Bromo-4'-Fluoroacetophenone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.