Description

(S)-Ibrutinib CAS NO 936563-97-2 is the S-enantiomer of the potent and selective Bruton's tyrosine kinase (BTK) inhibitor, Ibrutinib. This high-purity chiral intermediate is critical for pharmaceutical research and development, particularly in the synthesis of targeted therapeutics. It is essential for medicinal chemists and process development scientists working in oncology drug discovery and the production of novel kinase inhibitors.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of next-generation BTK inhibitors and related active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop enantiomerically pure drug candidates with optimized efficacy and safety profiles.
• Process Chemistry & Scale-up: Serves as a critical starting material or intermediate in the development and optimization of commercial-scale synthetic routes.
• Reference Standard: Employed as a high-purity analytical standard for method development, quality control, and regulatory submissions.
• Preclinical & Clinical Development: Utilized in the manufacture of drug substances for non-clinical and clinical trial materials.
• Asymmetric Synthesis Studies: Valuable compound for researching and developing novel chiral synthesis and resolution methodologies.

Basic Information

Product Name	(S)-Ibrutinib
CAS No.	936563-97-2
Molecular Formula	C25H24N6O2
Molecular Weight	440.50 g/mol
Synonyms	(S)-Ibrutinib; (S)-PCI-32765; (S)-1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one; (S)-Enantiomer of Ibrutinib; S-Ibrutinib; (S)-4-Amino-3-(4-phenoxyphenyl)-1-[(3R)-1-(2-propenoyl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine; BTK Inhibitor (S)-Enantiomer
EINECS	Contact for details

Quality Control

Our (S)-Ibrutinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.