Description

Ar-42 CAS NO 935881-37-1 is a potent and selective small molecule inhibitor of histone deacetylase (HDAC), specifically targeting Class I and IIb HDAC enzymes. This compound is a critical research tool for investigating epigenetic regulation, cellular differentiation, and apoptosis in various disease models. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, neurology, and metabolic disorders.

Application

• Biomedical Research: A key reagent for studying epigenetic mechanisms, gene expression, and chromatin remodeling in vitro and in vivo.
• Oncology Research: Investigation of anti-cancer properties, including induction of cell cycle arrest and apoptosis in various cancer cell lines.
• Neurological Disease Models: Used in research related to neurodegenerative conditions, neuroprotection, and neuronal differentiation.
• Inflammatory Disease Studies: Exploration of HDAC inhibition effects on immune cell function and inflammatory pathways.
• Chemical Biology: Serves as a reference standard and pharmacologic probe for validating HDAC-related assays and screening platforms.
• Preclinical Development: Supports early-stage drug discovery programs targeting HDACs for therapeutic intervention.

Basic Information

Product Name	Ar-42
CAS No.	935881-37-1
Molecular Formula	C₁₇H₁₄N₄O₂
Molecular Weight	306.32 g/mol
Synonyms	AR-42; OSU-HDAC42; (E)-N-Hydroxy-4-(3-methyl-2-phenylbut-1-en-1-yl)benzamide; HDAC Inhibitor AR-42; 4-[(1E)-3-Methyl-1-phenyl-1-buten-1-yl]-N-hydroxybenzamide; N-Hydroxy-4-[(1E)-3-methyl-1-phenyl-1-buten-1-yl]benzamide
EINECS	Contact for details

Quality Control

Our Ar-42 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure reproducibility and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.