Description

2,2,2-Trifluoro-1-(2-Hydroxy-4-Methylphenyl)-Ethanone is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its unique structure, featuring a trifluoroacetyl group adjacent to a phenolic hydroxyl, makes it a valuable precursor for creating complex molecules with enhanced properties. This compound is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs for improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the trifluoromethyl group can enhance biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized chelating ligands or organocatalysts used in asymmetric synthesis and metal complexation.
• Material Science Research: Employed in the development of advanced polymers, liquid crystals, or organic electronic materials where fluorine incorporation modifies electronic properties and stability.
• Chemical Biology Probes: Useful for synthesizing fluorescent tags or photoaffinity labels for studying biological systems and protein interactions.

Basic Information

Product Name	2,2,2-Trifluoro-1-(2-Hydroxy-4-Methylphenyl)-Ethanone
CAS No.	935534-21-7
Molecular Formula	C9H7F3O2
Molecular Weight	204.15 g/mol
Synonyms	1-(2-Hydroxy-4-methylphenyl)-2,2,2-trifluoroethanone; 2-Hydroxy-4-methyl-2',2',2'-trifluoroacetophenone; 2',2',2'-Trifluoro-2-hydroxy-4'-methylacetophenone; α,α,α-Trifluoro-2-hydroxy-4-methylacetophenone; 2,2,2-Trifluoro-1-(2-hydroxy-p-tolyl)ethanone; TFHMPE; Trifluoroacetyl Derivative of p-Cresol
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-(2-Hydroxy-4-Methylphenyl)-Ethanone is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) are available for every batch upon request, detailing all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.