Description

Pilaralisib CAS NO 934526-89-3 is a potent and selective small-molecule inhibitor of the phosphatidylinositol 3-kinase (PI3K) pathway, specifically targeting the p110δ isoform. This compound is a critical research tool and pharmaceutical intermediate for investigating and developing novel oncology therapeutics. It is essential for researchers and developers in the pharmaceutical and biotechnology sectors focused on targeted cancer therapies, particularly for hematological malignancies and solid tumors.

Application

• Pharmaceutical Research & Development: A key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel PI3Kδ inhibitor drugs.
• Preclinical Cancer Studies: Used extensively in in vitro and in vivo models to study the role of PI3Kδ signaling in tumor cell proliferation, survival, and metastasis.
• Biochemical Assay Development: Serves as a potent control compound in high-throughput screening (HTS) campaigns and enzymatic assays targeting the PI3K/Akt/mTOR pathway.
• Mechanism of Action (MoA) Studies: Employed to elucidate downstream signaling effects and potential combination therapies with other targeted agents or immunotherapies.
• Academic Research: Utilized in university and institutional labs for fundamental research into B-cell biology, immune cell regulation, and oncogenic signaling pathways.
• Process Chemistry & Scale-Up: Acts as a critical intermediate for process chemists during the optimization and kilogram-scale synthesis of related therapeutic candidates.

Basic Information

Product Name	Pilaralisib
CAS No.	934526-89-3
Molecular Formula	C21H21F3N6O2
Molecular Weight	446.43 g/mol
Synonyms	SAR245408; XL147; 5-(2,6-Di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-2-pyridinamine; (S)-Pilaralisib; UNII-6E3K6L7B2Q; Pilaralisib (SAR245408); XL-147
EINECS	Contact for details

Quality Control

Our Pilaralisib is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure compliance with research-grade and pharmaceutical intermediate standards. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, cool, and well-ventilated place. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.