Description

3'-Deoxy-2'-C-Methyluridine is a modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a critical building block and intermediate in the synthesis of novel antiviral and anticancer therapeutics. It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in nucleoside chemistry and drug discovery programs. The structural modification at the 2' and 3' positions of the ribose ring makes it a valuable precursor for probing biological mechanisms and developing targeted therapies.

Application

• Pharmaceutical Intermediate: Key synthetic precursor for the development of antiviral drugs, particularly those targeting RNA viruses.
• Anticancer Agent Research: Used in the research and synthesis of nucleoside-based chemotherapeutic candidates.
• Biochemical Research: Serves as a tool compound for studying enzyme mechanisms, such as those involving polymerases and nucleoside kinases.
• Prodrug Synthesis: Employed in the design and creation of prodrugs to enhance the bioavailability and targeting of active pharmaceutical ingredients (APIs).
• Labeled Compound Production: Acts as a starting material for synthesizing isotopically labeled (e.g., C13, N15) nucleosides for metabolic and pharmacokinetic studies.
• Oligonucleotide Synthesis: Can be incorporated into modified oligonucleotides for antisense or siRNA therapeutic applications.

Basic Information

Product Name	3'-Deoxy-2'-C-Methyluridine
CAS No.	934014-19-4
Molecular Formula	C11H16N2O5
Molecular Weight	256.26 g/mol
Synonyms	2'-C-Methyl-3'-deoxyuridine; 1-((2R,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 3'-Deoxy-2'-C-methyluridine; 2'-C-Methyl-3'-deoxy-uridine; 2'-Methyl-3'-deoxyuridine; β-2'-C-Methyl-3'-deoxyuridine
EINECS	Contact for details

Quality Control

Our 3'-Deoxy-2'-C-Methyluridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide a Certificate of Analysis (COA) with every shipment, detailing all specifications and test results to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.