Description

Methanone, (4-ethynylphenyl)(4-hydroxy-1-piperidinyl)- is a specialized organic compound featuring a unique molecular architecture combining an ethynylphenyl group with a hydroxy-substituted piperidine moiety. This structure makes it a valuable key intermediate in advanced organic synthesis, particularly for constructing complex pharmacologically active molecules. It is primarily sought after by pharmaceutical R&D and fine chemical sectors for the development of new therapeutic agents and high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other targeted therapies.
• Organic Synthesis Reagent: Used in advanced coupling reactions and as a precursor for creating complex heterocyclic compounds and molecular scaffolds.
• Chemical Research & Development: Serves as a key substrate in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Ligand and Catalyst Precursor: Potential use in the development of specialized ligands for catalysis or as a precursor for metal-organic frameworks (MOFs).
• Material Science Research: Investigated for incorporation into advanced polymers or functional materials due to its ethynyl and piperidine functional groups.

Basic Information

Product Name	Methanone, (4-ethynylphenyl)(4-hydroxy-1-piperidinyl)-
CAS No.	933986-68-6
Molecular Formula	C14H15NO2
Molecular Weight	229.28 g/mol
Synonyms	(4-Ethynylphenyl)(4-hydroxypiperidin-1-yl)methanone; 1-(4-Ethynylbenzoyl)-4-hydroxypiperidine; 4-Hydroxy-1-(4-ethynylbenzoyl)piperidine; 4-Ethynyl-N-(4-hydroxypiperidin-1-yl)benzamide (tautomeric form); 933986-68-6; (4-Ethynylphenyl)(4-hydroxy-1-piperidyl)methanone
EINECS	Contact for details

Quality Control

Our production of Methanone, (4-ethynylphenyl)(4-hydroxy-1-piperidinyl)- adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, and spectroscopic identification (IR, NMR). A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5% Total impurities ≤ 1.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.