Description

1-(4-Chloro-2-Fluoro-Phenyl)-Ethan-1-Ol is a high-purity fluorinated and chlorinated aromatic alcohol, serving as a critical chiral building block in advanced organic synthesis. Its unique structure provides a versatile platform for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This intermediate is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogenated phenyl motifs with a functionalizable alcohol handle.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel drug candidates, especially in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Building block for creating advanced herbicides, fungicides, and insecticides that require halogenated aromatic systems for enhanced bioactivity and environmental stability.
• Liquid Crystal & OLED Materials: Used in the research and production of fluorinated components for electronic display and lighting technologies.
• Complex Ligand Preparation: Serves as a precursor for chiral ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Fine Chemical Production: Intermediate in the multi-step synthesis of dyes, flavors, and fragrances requiring specific halogenated aromatic backbones.
• Academic & R&D: A valuable reagent for methodological studies in organic chemistry, including cross-coupling reactions and stereoselective transformations.

Basic Information

Product Name	1-(4-Chloro-2-Fluoro-Phenyl)-Ethan-1-Ol
CAS No.	933673-55-3
Molecular Formula	C8H8ClFO
Molecular Weight	174.60 g/mol
Synonyms	1-(4-Chloro-2-fluorophenyl)ethanol; (4-Chloro-2-fluorophenyl)methylcarbinol; α-Methyl-4-chloro-2-fluorobenzyl alcohol; 2-Fluoro-4-chloro-α-methylbenzyl alcohol; 1-(4-Chloro-2-fluoro-phenyl)-ethan-1-ol; 933673-55-3; 4-Chloro-2-fluoro-α-methylbenzyl alcohol
EINECS	Contact for details

Quality Control

Our 1-(4-Chloro-2-Fluoro-Phenyl)-Ethan-1-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% (Specific enantiomer available)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.