Description

Meayamycin CAS NO 933474-26-1 is a potent and selective small molecule inhibitor of the spliceosome, specifically targeting the SF3B complex. This compound is a critical research tool for studying RNA splicing mechanisms and their role in disease pathology. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology, antiviral, and genetic disorder research.

Application

• Biomedical Research: A key pharmacological probe for investigating pre-mRNA splicing, spliceosome function, and spliceosomal mutations in cancer.
• Anticancer Agent Development: Serves as a lead compound or reference standard in the discovery and validation of novel therapeutics targeting the spliceosome for various cancers.
• Mechanistic Studies: Used to elucidate the biological pathways and consequences of splicing inhibition in cell culture and animal models.
• Virology Research: Applied in studies exploring host splicing machinery as a target for developing broad-spectrum antiviral strategies.
• High-Throughput Screening (HTS): Employed as a control or benchmark compound in screening assays designed to identify new splicing modulators.
• Chemical Biology: Useful for creating chemical probes to study protein-RNA interactions within the spliceosome complex.

Basic Information

Product Name	Meayamycin
CAS No.	933474-26-1
Molecular Formula	C39H54N4O11
Molecular Weight	754.87 g/mol
Synonyms	Meayamycin; FR901464 analogue; Spliceostatin A analogue; SF3B1 inhibitor; (1R,2S,5S,7S,10R,11S,14S,15R,16S,32S,33R,34S,36R,37S)-14-[(2S,3S,4S,5S,6R)-4,5-Dihydroxy-6-methyl-3-(methylamino)oxan-2-yl]oxy-2,15,16-trihydroxy-7,11-dimethoxy-5,10-dimethyl-4,17,20,21,23,24,27,28,30,31,33,34,36,37-tetradecahydro-1H-12,29-methanodipyrido[2,1-f:3',2',1'-ij][1,7,10,16]tetraoxadiazacyclotetracosine-6,13,18,25-tetrone
EINECS	Contact for details

Quality Control

Our Meayamycin is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, LC-MS for identity confirmation, and NMR for structural verification, to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.