Description

Actinomycin F1 CAS NO 1402-44-4 is a potent antibiotic and antitumor agent belonging to the actinomycin family of chromopeptides. This compound is of significant interest for its ability to intercalate into DNA, inhibiting transcription and making it a valuable tool in biochemical research and a model for anticancer drug development. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on oncology and molecular biology.

Application

• Biochemical Research: Used as a specific inhibitor of DNA-dependent RNA synthesis to study transcription mechanisms.
• Anticancer Research: Serves as a reference compound and positive control in screening for novel chemotherapeutic agents.
• Molecular Biology: Employed in studies of nucleic acid structure and function, including chromatin remodeling and gene expression analysis.
• Pharmacology Studies: Utilized to investigate the mechanisms of drug resistance and combination therapies in cancer models.
• Cell Biology: Applied in research on apoptosis (programmed cell death) and cell cycle arrest.
• Microbiology: Acts as an antibiotic in selective media and studies of microbial genetics.

Basic Information

Product Name	Actinomycin F1
CAS No.	1402-44-4
Molecular Formula	C62H86N12O16
Molecular Weight	1279.44 g/mol
Synonyms	Actinomycin F1; Actinomycin C1; Actinomycin IV; Actinomycin AIV; Dactinomycin F1; Actinomycin F; Actinomycin C; 1402-44-4; NSC 19880; Antibiotic F1; Actinomycin F-1
EINECS	Contact for details

Quality Control

Our Actinomycin F1 is produced and handled under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The product is hygroscopic and light-sensitive; allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Red-orange to red crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 3.0%
Residue on Ignition	≤ 1.0%
Specific Optical Rotation	Contact for details
Biological Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.