Description

n-[2-(Bromomethyl)-4-Nitrophenyl]-2,2,2-Trifluoroacetimidoyl Chloride CAS NO 930775-33-0 is a specialized organic intermediate featuring a reactive bromomethyl group and a trifluoroacetimidoyl chloride moiety. This compound is highly valued for its role as a key building block in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working on novel active ingredients, where its unique structure enables critical functionalization and derivatization steps.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring halogenated aromatic or trifluoromethylated motifs.
• Agrochemical Research: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging its reactive sites for structural diversification.
• Chemical Biology & Proteomics: Serves as a versatile reagent for bioconjugation and the development of activity-based probes (ABPs) due to its electrophilic functional groups.
• Material Science: Employed in the synthesis of specialty polymers and advanced organic materials where its aromatic and halogenated structure imparts specific properties.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) facilitated by the bromomethyl handle.
• Fluorine Chemistry: A valuable synthon for introducing the trifluoromethylacetimidoyl group into target molecules, a moiety of high interest in medicinal chemistry for improving metabolic stability and lipophilicity.

Basic Information

Product Name	n-[2-(Bromomethyl)-4-Nitrophenyl]-2,2,2-Trifluoroacetimidoyl Chloride
CAS No.	930775-33-0
Molecular Formula	C9H5BrClF3N2O2
Molecular Weight	345.50 g/mol
Synonyms	2-(Bromomethyl)-N-(trichloroacetyl)aniline (related precursor); 2-(Bromomethyl)-4-nitro-N-(2,2,2-trifluoroacetyl)aniline; 1-[2-(Bromomethyl)-4-nitrophenyl]-2,2,2-trifluoroethanimidoyl chloride; N-[2-(Bromomethyl)-4-nitrophenyl]-2,2,2-trifluoroacetimidic acid chloride; 930775-33-0; Bromomethyl-nitrophenyl-trifluoroacetimidoyl chloride
EINECS	Contact for details

Quality Control

Our n-[2-(Bromomethyl)-4-Nitrophenyl]-2,2,2-Trifluoroacetimidoyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as identity, purity, and impurity profiles. Our quality management system is designed to meet the stringent requirements of advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.