Description

Cyclobutanone, 3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]- is a high-value, protected ketone derivative used as a critical synthetic intermediate in advanced organic chemistry. This compound is essential for researchers and manufacturers requiring precise stereochemistry and functional group manipulation in complex molecule construction. It is primarily utilized in the development of active pharmaceutical ingredients (APIs), agrochemicals, and novel materials where its unique silyl-protected hydroxyl group on the cyclobutanone ring enables sophisticated multi-step synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug candidates, particularly in medicinal chemistry programs targeting novel therapeutic agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the strained cyclobutanone ring for bioactive molecule design.
• Material Science Research: Serves as a precursor for specialized polymers and advanced organic materials with tailored properties.
• Asymmetric Synthesis: Valuable chiral synthon for constructing stereodefined molecular architectures in academic and industrial R&D settings.
• Process Chemistry Development: Employed in route scouting and optimization for scalable manufacturing of fine chemicals.
• Cross-Coupling Reactions: Functional intermediate for modern metal-catalyzed coupling reactions to form complex carbon-carbon bonds.

Basic Information

Product Name	Cyclobutanone, 3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-
CAS No.	929913-18-8
Molecular Formula	C11H22O2Si
Molecular Weight	214.38 g/mol
Synonyms	3-[(tert-Butyldimethylsilyl)oxy]cyclobutanone; 3-(TBDMSO)cyclobutanone; 3-(tert-Butyldimethylsiloxy)cyclobutanone; 3-(tert-Butyl-dimethyl-silanyloxy)-cyclobutanone; 3-TBDMS-Oxycyclobutanone; tert-Butyldimethyl(3-oxocyclobutyloxy)silane; Cyclobutanone, 3-[(tert-butyldimethylsilyl)oxy]-; 3-Oxocyclobutyl tert-butyldimethylsilyl ether
EINECS	Contact for details

Quality Control

Our Cyclobutanone, 3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]- is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC, GC, NMR, and IR spectroscopy. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.