Description

3-Fluoropicolinoyl Chloride is a versatile and highly reactive organofluorine building block, essential for introducing the 3-fluoropicolinoyl moiety into complex molecular architectures. Its primary value lies in enabling efficient and selective synthesis, making it a critical intermediate for advanced research and development. This compound is particularly sought after by pharmaceutical and agrochemical researchers for the development of novel active ingredients, as well as by material scientists exploring new functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluorinated picolinoyl group enhances biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating novel ligands used in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of specialty polymers, liquid crystals, and organic electronic materials that require fluorinated aromatic components.
• Custom Synthesis and Contract Manufacturing: A crucial reagent for fine chemical manufacturers offering bespoke synthesis services to the life sciences industry.
• Academic and R&D Laboratories: Used in fundamental organic chemistry research to study fluorination effects and develop new synthetic methodologies.

Basic Information

Product Name	3-Fluoropicolinoyl Chloride
CAS No.	929568-98-9
Molecular Formula	C6H3ClFNO
Molecular Weight	159.55 g/mol
Synonyms	3-Fluoropyridine-2-carbonyl chloride; 3-Fluoro-2-pyridinecarbonyl chloride; 2-Picolinoyl chloride, 3-fluoro-; 3-Fluoropicolinic acid chloride; 3-Fluoro-2-picolinoyl chloride; 3-Fluoropyridine-2-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our 3-Fluoropicolinoyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data to support its use in regulated environments. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every batch upon request, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition from moisture ingress. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.