Description

2-Chloro-1-(2,3-Difluorophenyl)Ethanone is a versatile fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both a reactive α-chloroketone moiety and difluorophenyl ring, makes it a critical precursor for constructing complex heterocyclic and pharmaceutical intermediates. This compound is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and fungicides, leveraging the biological activity of the difluorophenyl group.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic electronic materials for enhanced stability and performance.
• Custom Synthesis and Contract Manufacturing: A high-value starting material for custom synthesis houses serving the life sciences industry.

Basic Information

Product Name	2-Chloro-1-(2,3-Difluorophenyl)Ethanone
CAS No.	929249-82-1
Molecular Formula	C8H5ClF2O
Molecular Weight	190.57 g/mol
Synonyms	2-Chloro-1-(2,3-difluorophenyl)ethan-1-one; 2,3-Difluorophenacyl Chloride; α-Chloro-2,3-difluoroacetophenone; 1-(2,3-Difluorophenyl)-2-chloroethanone; 2-Chloro-2',3'-difluoroacetophenone; 929249-82-1; Ethanone, 2-chloro-1-(2,3-difluorophenyl)-
EINECS	Contact for details

Quality Control

Our 2-Chloro-1-(2,3-Difluorophenyl)Ethanone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications. We support cGMP standards for pharmaceutical applications and can accommodate custom purity requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and fluorides. The container must be kept tightly closed to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.