Description

Gsk461364 is a potent and selective small molecule inhibitor of Polo-like kinase 1 (PLK1), a key regulator of cell cycle progression. This compound is a critical research tool for studying mitosis, cell division, and oncology pathways in preclinical models. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies focused on cancer drug discovery and development.

Application

• Biochemical Research: Used as a selective PLK1 inhibitor to study kinase function, signal transduction, and mitotic regulation in cell-free systems.
• Cell Biology Studies: Essential for investigating the role of PLK1 in centrosome maturation, spindle assembly, and chromosome segregation in various cell lines.
• Oncology & Cancer Research: A vital tool for evaluating anti-mitotic therapeutic strategies, understanding tumor cell proliferation, and validating PLK1 as a drug target in vitro and in vivo.
• Drug Discovery & Development: Serves as a reference compound and a starting point for structure-activity relationship (SAR) studies in medicinal chemistry programs targeting PLK1.
• Pharmacology & Toxicology: Employed in preclinical studies to assess efficacy, pharmacokinetics, and safety profiles of PLK1 inhibition.

Basic Information

Product Name	Gsk461364
CAS No.	929095-18-1
Molecular Formula	C20H21ClFN5O2S
Molecular Weight	457.93 g/mol
Synonyms	GSK461364; GSK-461364; GSK 461364; 6-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-N-((1R)-1-(3-fluorophenyl)ethyl)-5-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxamide; PLK1 Inhibitor GSK461364; BI 2536 analog
EINECS	Contact for details

Quality Control

Our Gsk461364 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.