Description

Pracinostat CAS NO 929016-96-6 is a potent and selective small-molecule inhibitor of histone deacetylases (HDACs), specifically targeting Class I and II HDAC enzymes. This compound matters as a key research-grade active pharmaceutical ingredient (API) for investigating novel therapeutic pathways in oncology. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on developing treatments for hematological malignancies and solid tumors.

Application

• Pharmaceutical Research & Development (R&D): Serves as a critical reference standard and active pharmaceutical ingredient (API) in preclinical and clinical-stage research for new cancer therapies.
• Oncology Drug Discovery: Used in biochemical and cellular assays to study HDAC inhibition mechanisms and evaluate anti-proliferative effects on various cancer cell lines.
• Combination Therapy Studies: Investigated for synergistic effects when used in combination with other agents, such as azacitidine, for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).
• Epigenetics Research: A vital tool for scientists studying epigenetic modulation, gene expression, and chromatin remodeling in disease models.
• Biomarker & Pharmacodynamics Studies: Employed to understand the relationship between HDAC inhibition, biomarker expression, and therapeutic outcomes.
• Formulation Development: Used in the development and stability testing of various dosage forms intended for clinical use.

Basic Information

Product Name	Pracinostat
CAS No.	929016-96-6
Molecular Formula	C₂₁H₂₀N₄O₄
Molecular Weight	392.41 g/mol
Synonyms	SB939; N-Hydroxy-4-[[(2S)-2-(1H-indol-3-yl)-1-oxopropyl]amino]methyl]benzamide; Pracinostat (SB939); 4-[[[(2S)-2-(1H-Indol-3-yl)-1-oxopropyl]amino]methyl]-N-hydroxybenzamide; HDAC Inhibitor SB939; SB 939; UNII-7Q74S8R1QO
EINECS	Contact for details

Quality Control

Our Pracinostat is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards for research chemicals and can provide material suitable for advanced pharmaceutical development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccated environment after opening.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity: ≤0.5% Total impurities: ≤2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.