Description

Golvatinib (E7050) is a potent and selective small-molecule inhibitor targeting c-Met and VEGFR2 kinases, identified by the CAS number 928037-13-2. This compound is a critical research tool for investigating signaling pathways involved in tumor angiogenesis, proliferation, and metastasis. It is primarily needed by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on oncology drug discovery and preclinical development.

Application

• Oncology Research: Used as a reference standard and active pharmaceutical ingredient (API) in studies targeting c-Met and VEGFR2 signaling pathways.
• Drug Discovery & Development: Serves as a key pharmacological tool for in vitro and in vivo efficacy testing in various cancer models.
• Biochemical Assays: Employed in high-throughput screening (HTS) and enzyme inhibition assays to study kinase activity and selectivity.
• Mechanism of Action Studies: Facilitates research into tumor angiogenesis, invasion, and resistance mechanisms.
• Preclinical Formulation: Used in the development and testing of novel drug delivery systems for targeted cancer therapies.
• Reference Standard: Provides a qualified standard for analytical method development, validation, and quality control in API manufacturing.

Basic Information

Product Name	Golvatinib (E7050)
CAS No.	928037-13-2
Molecular Formula	C₂₉H₂₈FN₅O₃
Molecular Weight	513.56 g/mol
Synonyms	E7050; Golvatinib; UNII-8QZ74114A9; (3Z)-5-[(2,6-Dichlorophenyl)methylsulfanyl]-3-[[3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl]methylidene]-1,3-dihydro-2H-indol-2-one; N-[3-Fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
EINECS	Contact for details

Quality Control

Our Golvatinib (E7050) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurities is provided to ensure compliance with research-grade standards and support regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the container should be sealed under dry conditions and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.