Description

4-(Difluoromethoxy)-2,3-Dihydro-1H-Inden-1-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluoromethoxy-substituted indanone core structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), where its specific fluorinated moiety can significantly enhance metabolic stability and bioavailability. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in areas requiring sophisticated molecular building blocks.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the difluoromethoxy group can improve activity and environmental profile.
• Material Science Precursor: Serves as a specialized monomer or precursor for advanced polymers and functional materials with specific optical or electronic properties.
• Organic Synthesis Reagent: Employed in academic and industrial R&D for constructing complex fluorinated organic molecules.
• Ligand & Catalyst Development: Utilized in the design of novel ligands and catalysts for asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	4-(Difluoromethoxy)-2,3-Dihydro-1H-Inden-1-One
CAS No.	927406-20-0
Molecular Formula	C10H8F2O2
Molecular Weight	198.17 g/mol
Synonyms	4-(Difluoromethoxy)-2,3-dihydro-1-oxo-1H-indene; 4-(Difluoromethoxy)-1-indanone; 1H-Inden-1-one, 4-(difluoromethoxy)-2,3-dihydro-; 4-(Difluoromethoxy)indan-1-one; 927406-20-0; 4-(Difluoromethoxy)-1-indanone; 4-DFMO-Indanone
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)-2,3-Dihydro-1H-Inden-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.