Description

3′-o-Allyl Dg is a specialized nucleoside derivative used as a key building block in oligonucleotide synthesis. This compound is critical for researchers and manufacturers developing modified nucleic acids for therapeutic and diagnostic applications. It is primarily utilized in the pharmaceutical and biotechnology sectors for the production of antisense oligonucleotides, aptamers, and other advanced genetic tools.

Application

• Oligonucleotide Synthesis: Serves as a phosphoramidite precursor for the solid-phase synthesis of DNA/RNA strands.
• Antisense Drug Development: Used in the research and production of antisense oligonucleotides (ASOs) for targeted gene silencing therapies.
• Aptamer Production: A key monomer for creating modified aptamers with enhanced binding affinity and stability.
• siRNA and miRNA Research: Employed in the synthesis of small interfering RNA (siRNA) and microRNA (miRNA) analogs for functional genomics studies.
• Diagnostic Probe Fabrication: Incorporated into nucleic acid probes for diagnostic assays and biosensors.
• Bioconjugation: The allyl group provides a handle for further chemical modification and conjugation with other molecules.

Basic Information

Product Name	3′-o-Allyl Dg
CAS No.	925915-33-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	3′-O-Allyl-2′-deoxyguanosine; 2′-Deoxyguanosine, 3′-O-2-propen-1-yl-; 3′-O-Allyl-2′-deoxy-Guanosine; 3′-Allyloxy-2′-deoxyguanosine; N-(9-((2R,4S,5R)-4-Allyloxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)formamide; Allyl 2'-deoxyguanosine 3'-ether
EINECS	Contact for details

Quality Control

Our 3′-o-Allyl Dg is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive research and cGMP manufacturing. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.