Description

Abt-263 CAS NO 923564-51-6 is a potent, orally bioavailable small molecule inhibitor of the Bcl-2 family of anti-apoptotic proteins. This compound is of significant interest for its role in inducing programmed cell death (apoptosis) in various cell types. It is primarily utilized by researchers in the pharmaceutical and biotechnology sectors for drug discovery, preclinical studies, and as a critical reference standard in the development of novel cancer therapeutics.

Application

• Pharmaceutical Research & Development: As a key chemical entity in the discovery and optimization of novel oncology drugs targeting apoptosis pathways.
• Preclinical Studies: Used in in vitro and in vivo models to investigate the efficacy and mechanism of Bcl-2 inhibition for cancer treatment.
• Biochemical Assays: Serves as a high-purity reference compound in screening assays to identify and characterize new Bcl-2 family protein inhibitors.
• Academic Research: Employed in university and institutional labs for fundamental studies on cell death, cancer biology, and signal transduction.
• Reference Standard: Used for quality control, method development, and calibration in analytical laboratories (HPLC, LC-MS).
• Chemical Intermediate: May serve as a building block or precursor for the synthesis of more complex drug candidates or labeled analogs.

Basic Information

Product Name	Abt-263
CAS No.	923564-51-6
Molecular Formula	C47H55ClF3N5O6S3
Molecular Weight	974.66 g/mol
Synonyms	Navitoclax; ABT-263; 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(2R)-4-morpholin-2-yl]phenyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide; Bcl-2 Family Protein Inhibitor ABT-263
EINECS	Contact for details

Quality Control

Our Abt-263 is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.