Description

Refametinib is a potent and selective allosteric inhibitor of MEK1 and MEK2, key kinases in the RAS/RAF/MEK/ERK signaling pathway. This compound is of significant interest in oncology research for its potential to inhibit tumor growth and proliferation driven by MAPK pathway mutations. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and CROs for preclinical studies and drug discovery programs targeting cancers such as hepatocellular carcinoma and other solid tumors.

Application

• Oncology Research & Drug Discovery: A key investigational agent for studying the inhibition of the MAPK/ERK pathway in various cancer cell lines and animal models.
• Preclinical Development: Used in pharmacokinetic (PK), pharmacodynamic (PD), and toxicology studies to support the development of novel cancer therapeutics.
• Biochemical Assays: Serves as a reference standard and tool compound in high-throughput screening (HTS) and enzymatic assays to discover and validate new MEK inhibitors.
• Mechanistic Studies: Employed to elucidate the role of MEK signaling in disease progression, resistance mechanisms, and combination therapy strategies.
• Reference Standard: Used for analytical purposes, including method development and validation in HPLC, LC-MS, and NMR for quality control in API manufacturing.

Basic Information

Product Name	Refametinib
CAS No.	923032-37-5
Molecular Formula	C23H21F3IN3O3
Molecular Weight	579.33 g/mol
Synonyms	RDEA119; BAY 86-9766; (S)-N-(3,4-Difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide; ARRY-334543 (racemate); MEK Inhibitor RDEA119
EINECS	Contact for details

Quality Control

Our Refametinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support regulatory filings with detailed documentation. Certificates of Analysis (COA) are available upon request, detailing results for assay, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Due to its hygroscopic nature, the container should be kept sealed under inert atmosphere (e.g., nitrogen or argon) when not in use to prevent moisture absorption. Long-term storage recommendations are available in the product's technical data sheet.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.