Description

[5-Methyl-3-(Trifluoromethyl)-1H-Pyrazol-1-Yl]Acetyl Chloride is a high-value, reactive chemical intermediate featuring a pyrazole core functionalized with a trifluoromethyl group and an acid chloride moiety. This compound is critical for introducing the biologically active 5-methyl-3-(trifluoromethyl)pyrazole pharmacophore into target molecules via efficient acylation reactions. It is primarily sought by R&D and process development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting inflammation, metabolic disorders, and central nervous system (CNS) diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethylpyrazole moiety enhances lipophilicity and metabolic stability.
• Material Science Research: Serves as a precursor for creating specialized polymers, ligands, or metal-organic frameworks (MOFs) with unique electronic or surface properties.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects requiring precise functionalization of complex molecules.
• Bioconjugation & Probe Development: The reactive acid chloride group enables coupling to amines in peptides, proteins, or fluorescent tags for creating biochemical probes and diagnostic tools.

Basic Information

Product Name	[5-Methyl-3-(Trifluoromethyl)-1H-Pyrazol-1-Yl]Acetyl Chloride
CAS No.	922516-43-6
Molecular Formula	C8H6ClF3N2O
Molecular Weight	238.59 g/mol
Synonyms	1H-Pyrazole-1-acetyl chloride, 5-methyl-3-(trifluoromethyl)-; 2-[5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl chloride; (5-Methyl-3-trifluoromethyl-1H-pyrazol-1-yl)acetyl chloride; 5-Methyl-3-(trifluoromethyl)-1H-pyrazole-1-acetyl chloride; NSC 796082; Acetyl chloride, [5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-; MFCD23123521
EINECS	Contact for details

Quality Control

Our production of [5-Methyl-3-(Trifluoromethyl)-1H-Pyrazol-1-Yl]Acetyl Chloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical synthesis applications. All material is characterized by advanced analytical techniques including NMR, HPLC, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases, oxidizers, and sources of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.