Description

2'-Tbdms-5-Me-Ru CAS NO 922508-26-7 is a high-purity, protected nucleoside derivative, specifically a 2'-O-tert-butyldimethylsilyl (TBDMS) modified ribonucleoside analog. This compound is a critical building block in oligonucleotide synthesis, particularly for the development of RNA-based therapeutics and diagnostic tools. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require reliable, high-quality intermediates for antisense oligonucleotides, siRNA, and other advanced nucleic acid constructs.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified RNA strands.
• Therapeutic RNA Development: Used in the research and production of siRNA (small interfering RNA) and antisense oligonucleotides for targeted gene silencing.
• Diagnostic Probe Manufacturing: Serves as a modified base in the creation of sensitive and specific molecular probes for diagnostic assays.
• Academic & Industrial Research: A vital reagent for studying RNA structure, function, and stability in biochemistry and molecular biology laboratories.
• Pharmaceutical Intermediates: An important intermediate in the cGMP-compliant manufacturing process for novel RNA-based drugs.

Basic Information

Product Name	2'-Tbdms-5-Me-Ru
CAS No.	922508-26-7
Molecular Formula	C17H30N2O6Si
Molecular Weight	386.52 g/mol
Synonyms	2'-O-TBDMS-5-Methyluridine; 5-Methyl-2'-O-(tert-butyldimethylsilyl)uridine; 2'-O-(tert-Butyldimethylsilyl)-5-methyluridine; 5-Me-2'-TBDMS-Ur; TBDMS-5-Me-Ur; 922508-26-7; 2'-TBDMS-5-methyl-Uridine; 5-Methyluridine, 2'-O-[(1,1-dimethylethyl)dimethylsilyl]-
EINECS	Contact for details

Quality Control

Our 2'-Tbdms-5-Me-Ru is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications. Our quality commitment supports applications requiring high standards, from research to cGMP-grade pharmaceutical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., argon or nitrogen) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.