Description

Bosutinib Methanoate is a high-purity, small molecule pharmaceutical intermediate and reference standard. This compound is critical for research and development in the field of targeted cancer therapies, specifically as a key precursor in the synthesis of the tyrosine kinase inhibitor Bosutinib. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions engaged in oncology drug discovery, process development, and analytical method validation.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the multi-step synthesis of the active pharmaceutical ingredient (API) Bosutinib.
• Reference Standard: Used for analytical purposes, including method development, validation, and quality control (QC) testing of Bosutinib API and related formulations.
• Biochemical Research: Employed in in vitro studies to investigate kinase inhibition pathways and structure-activity relationships (SAR).
• Process Development: Aids in the optimization and scaling of manufacturing processes for Bosutinib in GMP environments.
• Impurity Profiling: Acts as a known impurity or degradation product marker during stability studies and impurity identification programs.

Basic Information

Product Name	Bosutinib Methanoate
CAS No.	918639-10-8
Molecular Formula	C26H29Cl2N5O3
Molecular Weight	530.45 g/mol
Synonyms	Bosutinib Methanoate Salt; 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile methanoate; SKI-606 Methanoate; 918639-10-8; Bosutinib Formate; Bosutinib Monomethanoate
EINECS	Contact for details

Quality Control

Our Bosutinib Methanoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support regulatory filings. A detailed Certificate of Analysis (COA) is available for every lot, confirming compliance with client specifications and relevant industry guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.