Description

Plx4032 is a high-purity, small-molecule compound of significant interest in pharmaceutical research and development. This compound serves as a critical intermediate or active pharmaceutical ingredient (API) in the synthesis of targeted therapies. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in oncology and other life science research. Our supply ensures consistent quality and reliable availability for critical development workflows.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs).
• Oncology Research: Used in preclinical and clinical research for developing targeted cancer therapies.
• Biochemical Assay Development: Serves as a reference standard or inhibitor in high-throughput screening and assay validation.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale manufacturing for drug candidates.
• Academic Research: Utilized in university and institutional labs for mechanistic studies and drug discovery projects.
• Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials and commercial APIs under cGMP guidelines.

Basic Information

Product Name	Plx4032
CAS No.	918504-65-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Vemurafenib Intermediate; PLX-4032; RG7204; RO5185426; 5-(4-Chlorophenyl)-1-(propan-2-yl)-N-[2-(propan-2-yl)sulfonyl]phenyl]-1H-pyrazole-4-carboxamide (related derivative); BRAF Inhibitor Intermediate; Protein kinase inhibitor intermediate
EINECS	Contact for details

Quality Control

Our Plx4032 is manufactured and controlled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling using techniques such as HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support development under various quality paradigms, including research-grade and cGMP standards for advanced clinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC, Area%)	≥99.0%
Single Maximum Impurity	≤0.5%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.