Description

(S,E)-n-(2-(tert-Butyldimethylsilyloxy)Ethylidene)-2-Methylpropane-2-Sulfinamide is a high-purity chiral sulfinamide reagent, a critical building block in asymmetric synthesis. Its primary value lies in its role as a versatile chiral auxiliary and ligand for the stereoselective construction of complex molecules, particularly in pharmaceutical intermediates. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require high enantiomeric purity for advanced synthetic routes. The CAS number for this compound is 918413-70-4.

Application

• Asymmetric Synthesis: Employed as a chiral auxiliary in the stereoselective addition of nucleophiles to imines for the synthesis of enantiomerically pure amines.
• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) requiring specific stereochemistry.
• Ligand for Catalysis: Used in the preparation of chiral metal complexes for catalytic asymmetric transformations.
• Agrochemical Research: Utilized in the development of chiral herbicides, fungicides, and insecticides where biological activity is stereospecific.
• Academic & Process R&D: A valuable tool for methodology development and scaling up enantioselective reactions in laboratory and pilot plant settings.
• Fine Chemical Production: Integral to the manufacture of specialty chemicals, flavors, and fragrances with defined stereocenters.

Basic Information

Product Name	(S,E)-n-(2-(tert-Butyldimethylsilyloxy)Ethylidene)-2-Methylpropane-2-Sulfinamide
CAS No.	918413-70-4
Molecular Formula	C₁₂H₂₇NO₂SSi
Molecular Weight	277.50 g/mol
Synonyms	(S,E)-N-(2-((tert-Butyldimethylsilyl)oxy)ethylidene)-2-methylpropane-2-sulfinamide; (S,E)-N-(2-(tert-Butyldimethylsilanyloxy)ethylidene)-2-methyl-propane-2-sulfinamide; (S,E)-tert-Butanesulfinamide TBS ether; (S,E)-N-(2-(tert-Butyldimethylsilyloxy)vinyl)-2-methylpropane-2-sulfinamide; Ellman Sulfinamide TBS Ether; Chiral Sulfinyl Imine TBS Protected; (S)-tert-Butanesulfinamide, (E)-O-(tert-butyldimethylsilyl) derivative
EINECS	Contact for details

Quality Control

Our (S,E)-n-(2-(tert-Butyldimethylsilyloxy)Ethylidene)-2-Methylpropane-2-Sulfinamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. Due to its hygroscopic (moisture-sensitive) nature, the container should be sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to maintain product integrity and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.