Description

n-[2-(Bromomethyl)Phenyl]-2,2-Difluoroacetimidoyl Chloride CAS NO 916911-80-3 is a high-value, multi-functional organic intermediate characterized by its reactive bromomethyl and difluoroacetimidoyl chloride groups. This compound is critical for the synthesis of complex molecules, particularly in advanced pharmaceutical research and agrochemical development. It is primarily sought after by R&D chemists and process development scientists in the fine chemical and life sciences industries for constructing novel heterocyclic scaffolds and introducing difluoromethyl motifs, which are pivotal in modern drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing difluoromethyl ether or difluoromethylated heterocycles to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoromethyl group can improve activity and environmental profile.
• Material Science Research: Serves as a precursor for specialty polymers and functional materials that require halogenated or fluorinated aromatic units.
• Ligand and Catalyst Development: Employed in the creation of novel organocatalysts or metal-organic complexes for asymmetric synthesis.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags used in biochemical assays and diagnostic research due to its reactive handles.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global pharmaceutical and agrochemical sectors.

Basic Information

Product Name	n-[2-(Bromomethyl)Phenyl]-2,2-Difluoroacetimidoyl Chloride
CAS No.	916911-80-3
Molecular Formula	C9H7BrClF2NO
Molecular Weight	298.51 g/mol
Synonyms	2,2-Difluoro-N-[2-(bromomethyl)phenyl]acetimidoyl chloride; 1-[2-(Bromomethyl)phenyl]-2,2-difluoroethanimidoyl chloride; N-(2-Bromobenzyl)-2,2-difluoroacetimidoyl chloride; 2-(Bromomethyl)benzenecarboximidoyl chloride, 2,2-difluoro-; α,α-Difluoro-N-(o-bromobenzyl)acetimidoyl chloride; 916911-80-3; (2-Bromobenzyl)(chloro)difluoroacetimidate
EINECS	Contact for details

Quality Control

Our n-[2-(Bromomethyl)Phenyl]-2,2-Difluoroacetimidoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 96.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.