Description

n-(o-Tolyl)-2,2-Difluoroacetimidoyl Chloride is a specialized organic intermediate featuring a reactive imidoyl chloride group and difluoroacetate moiety. This compound is valued for its role as a key building block in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists in the fine chemical and pharmaceutical industries for constructing novel heterocycles and active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, leveraging the difluoroacetate group for enhanced biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers with unique fluorinated properties.
• Ligand and Catalyst Development: Employed in organometallic chemistry for the creation of novel ligands and catalysts used in asymmetric synthesis.
• Fluorinated Compound Library Synthesis: A key reagent for medicinal chemistry teams building diverse compound libraries for high-throughput screening (HTS).
• Academic Research: Utilized in university and institutional labs for methodological studies in organic synthesis and fluorine chemistry.

Basic Information

Product Name	n-(o-Tolyl)-2,2-Difluoroacetimidoyl Chloride
CAS No.	916910-97-9
Molecular Formula	C9H8ClF2NO
Molecular Weight	219.62 g/mol
Synonyms	2,2-Difluoro-N-(2-methylphenyl)ethanimidoyl chloride; N-(2-Methylphenyl)-2,2-difluoroacetimidoyl chloride; o-Tolyl-2,2-difluoroacetimidoyl chloride; 2,2-Difluoroacetimidoyl chloride, N-(o-tolyl)-; 916910-97-9; N-(2-Methylphenyl)-2,2-difluoroethanimidoyl chloride; Difluoroacetimidoyl chloride, N-(o-tolyl)-
EINECS	Contact for details

Quality Control

Our n-(o-Tolyl)-2,2-Difluoroacetimidoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.