Description

Benzenesulfonamide,5-[[5-Fluoro-4-[[4-(2-Propyn-1-Yloxy)Phenyl]Amino]-2-Pyrimidinyl]Amino]-2-Methyl- is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of targeted therapeutic agents. Its complex molecular structure, featuring a benzenesulfonamide core linked to a substituted pyrimidine, makes it a critical building block for research and development in medicinal chemistry. This compound is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted kinase inhibitors for oncology and inflammatory disease research.
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies and lead optimization.
• Biochemical Assay Development: Serves as a reference standard or probe compound in high-throughput screening and enzyme inhibition assays.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis for creating complex, biologically active molecules.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in the custom synthesis of novel active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for drug discovery projects and chemical biology studies.

Basic Information

Product Name	Benzenesulfonamide,5-[[5-Fluoro-4-[[4-(2-Propyn-1-Yloxy)Phenyl]Amino]-2-Pyrimidinyl]Amino]-2-Methyl-
CAS No.	916741-98-5
Molecular Formula	C22H19FN6O3S
Molecular Weight	466.49 g/mol
Synonyms	5-[[5-Fluoro-4-[[4-(2-Propyn-1-yloxy)phenyl]amino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide; 2-Methyl-5-((5-fluoro-4-((4-(prop-2-yn-1-yloxy)phenyl)amino)pyrimidin-2-yl)amino)benzenesulfonamide; N-(5-Fluoro-4-((4-(prop-2-yn-1-yloxy)phenyl)amino)pyrimidin-2-yl)-2-methyl-5-sulfamoylbenzamide (related); Kinase Inhibitor Intermediate 916741-98-5; BSM-FPPA; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of Benzenesulfonamide,5-[[5-Fluoro-4-[[4-(2-Propyn-1-Yloxy)Phenyl]Amino]-2-Pyrimidinyl]Amino]-2-Methyl- adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider using an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.