Description

3'-Methoxy-5'-(Trifluoromethyl)Acetophenone is a high-value trifluoromethylated aromatic ketone building block, essential for advanced organic synthesis. Its core value lies in the unique combination of the electron-donating methoxy group and the electron-withdrawing trifluoromethyl group, which enables precise tuning of molecular properties. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly where enhanced metabolic stability and lipophilicity are required.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitors and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the trifluoromethyl group improves biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic semiconductors and liquid crystal materials due to its specific electronic properties.
• Fluorine Chemistry Studies: A valuable reference compound for investigating structure-activity relationships (SAR) in fluorinated aromatic systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales.

Basic Information

Product Name	3'-Methoxy-5'-(Trifluoromethyl)Acetophenone
CAS No.	916421-06-2
Molecular Formula	C10H9F3O2
Molecular Weight	218.17 g/mol
Synonyms	1-[3-Methoxy-5-(trifluoromethyl)phenyl]ethanone; 3-Methoxy-5-(trifluoromethyl)acetophenone; 3-Methoxy-α,α,α-trifluoro-m-acetophenone; 3-Methoxy-5-trifluoromethylacetophenone; 3'-Methoxy-5'-trifluoromethyl acetophenone; 1-(3-Methoxy-5-(trifluoromethyl)phenyl)ethan-1-one; m-Methoxy-α,α,α-trifluoroacetophenone (related isomer)
EINECS	Contact for details

Quality Control

Our 3'-Methoxy-5'-(Trifluoromethyl)Acetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with ISO standards and meets the stringent requirements for pharmaceutical R&D and cGMP (current Good Manufacturing Practice) starting materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed when not in use to prevent moisture absorption and potential contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.