Description

3'-Methyl-5'-(Trifluoromethoxy)Acetophenone is a high-purity, fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its core value lies in the unique trifluoromethoxy (OCF₃) substituent, which is prized for its ability to modulate the lipophilicity, metabolic stability, and bioavailability of target molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the construction of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in areas targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethoxy group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated aromatic cores for electronic display materials and organic light-emitting diodes (OLEDs).
• Advanced Material Science: Employed in the creation of specialty polymers and coatings with tailored surface properties and chemical resistance.
• Chemical Research & Development: A versatile building block for method development and exploration of novel fluorination chemistry in academic and industrial R&D labs.

Basic Information

Product Name	3'-Methyl-5'-(Trifluoromethoxy)Acetophenone
CAS No.	916420-58-1
Molecular Formula	C₁₀H₉F₃O₂
Molecular Weight	218.17 g/mol
Synonyms	1-[3-Methyl-5-(trifluoromethoxy)phenyl]ethanone; 3-Methyl-5-(trifluoromethoxy)acetophenone; 3'-Methyl-5'-(trifluoromethoxy)acetophenone; 1-(3-Methyl-5-(trifluoromethoxyl)phenyl)ethan-1-one; 3-Methyl-5-trifluoromethoxyacetophenone; 3-Methyl-5-(trifluoromethoxy)phenyl methyl ketone; 3-Methyl-α,α,α-trifluoro-p-methoxyacetophenone
EINECS	Contact for details

Quality Control

Our 3'-Methyl-5'-(Trifluoromethoxy)Acetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.