Description

3-Methyl-5-(Trifluoromethoxy)Benzoyl Chloride is a high-purity, reactive aromatic acid chloride derivative. This compound serves as a critical building block in advanced organic synthesis, enabling the efficient introduction of the 3-methyl-5-(trifluoromethoxy)benzoyl moiety. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the trifluoromethoxy aromatic group for enhanced metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the specific substitution pattern contributes to biological activity.
• Ligand and Material Science: Building block for creating specialized ligands for catalysis or monomers for high-performance polymers with unique properties.
• Peptide Coupling Reagent: Functions as an activating agent for carboxylic acids in amide bond formation, a fundamental reaction in medicinal chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CMOs for client-specific research projects and scale-up campaigns.

Basic Information

Product Name	3-Methyl-5-(Trifluoromethoxy)Benzoyl Chloride
CAS No.	916420-52-5
Molecular Formula	C9H6ClF3O2
Molecular Weight	238.59 g/mol
Synonyms	3-Methyl-5-(trifluoromethoxy)benzoyl chloride; 5-(Trifluoromethoxy)-m-toluoyl chloride; 3-Methyl-5-(trifluoromethoxy)benzoic acid chloride; m-Methyl-α,α,α-trifluoro-p-cresyl carbonyl chloride; 916420-52-5; Benzoyl chloride, 3-methyl-5-(trifluoromethoxy)-; 3-Methyl-5-(trifluoromethoxy)benzoylchloride
EINECS	Contact for details

Quality Control

Every batch of 3-Methyl-5-(Trifluoromethoxy)Benzoyl Chloride is produced and tested under a strict quality management system. We guarantee high chemical purity and consistency, supported by comprehensive analytical documentation. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles (via HPLC, GC, NMR) is provided with each shipment to ensure it meets your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, alcohols, and moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.