Description

Dovitinib is a potent and selective small-molecule inhibitor targeting multiple receptor tyrosine kinases (RTKs), including fibroblast growth factor receptors (FGFRs) and vascular endothelial growth factor receptors (VEGFRs). This compound is of significant interest in pharmaceutical research and development for its potential therapeutic applications in oncology. It is primarily utilized by research institutions, pharmaceutical companies, and biotechnology firms engaged in the discovery and development of novel cancer treatments. Dovitinib CAS NO 915769-50-5 represents a critical tool for investigating signaling pathways involved in tumor growth and angiogenesis.

Application

• Pharmaceutical R&D: Serves as a key reference standard and active pharmaceutical ingredient (API) in the development of targeted cancer therapies.
• Preclinical Studies: Used in in vitro and in vivo models to evaluate efficacy against various cancer cell lines, including those with FGFR and VEGFR pathway dependencies.
• Biochemical Assays: Employed as a selective inhibitor in kinase profiling and enzymatic assays to study signal transduction mechanisms.
• Mechanism of Action Research: Facilitates the investigation of tumor angiogenesis, proliferation, and metastasis pathways for academic and industrial research.
• Drug Formulation Development: Used in stability studies and the development of dosage forms for clinical trial materials.

Basic Information

Product Name	Dovitinib
CAS No.	915769-50-5
Molecular Formula	C₂₁H₂₁FN₆O
Molecular Weight	392.43 g/mol
Synonyms	TKI-258; CHIR-258; (1E)-1-[4-(Diethylamino)butyl]-3-[(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-1,3-dihydro-2H-indol-2-one; 4-Amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one; Dovitinib lactate; Dovitinib dilactic acid
EINECS	Contact for details

Quality Control

Our Dovitinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation (IR, MS) to ensure it meets high-grade standards suitable for research and development. Certificates of Analysis (COA) with detailed chromatograms and spectroscopic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.