Description

5H-Imidazo[1,2-B]Pyrazole-2-Carbonyl Chloride is a high-value, reactive chemical intermediate essential for constructing complex heterocyclic scaffolds. Its primary value lies in its carbonyl chloride functional group, which enables efficient amide bond formation and serves as a key building block in medicinal chemistry. This compound is critically needed by pharmaceutical R&D teams and fine chemical manufacturers focused on developing novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring imidazopyrazole-based structures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new pesticides and herbicides that leverage the imidazopyrazole core for bioactivity.
• Material Science: Serves as a building block for advanced organic materials, including ligands for catalysts and functional polymers.
• Academic & Contract Research: Employed in university and CRO laboratories for method development and exploratory synthesis of heterocyclic compounds.
• Peptide Mimetics: Facilitates the introduction of the imidazopyrazole moiety into peptide chains to modify stability and receptor binding properties.

Basic Information

Product Name	5H-Imidazo[1,2-B]Pyrazole-2-Carbonyl Chloride
CAS No.	914637-81-3
Molecular Formula	C6H4ClN3O
Molecular Weight	169.57 g/mol
Synonyms	5H-Imidazo[1,2-b]pyrazole-2-carbonyl chloride; Imidazo[1,2-b]pyrazole-2-carbonyl chloride; 2-Carbonyl chloride-5H-imidazo[1,2-b]pyrazole; 914637-81-3; 5H-Imidazo[1,2-b]pyrazole-2-carboxylic acid chloride; Imidazo[1,2-b]pyrazole-2-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our production of 5H-Imidazo[1,2-B]Pyrazole-2-Carbonyl Chloride adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.