Description

2-Chloro-2-Fluoro-2-[4-(Trifluoromethyl)Phenyl]Acetyl Fluoride is a highly functionalized, multi-fluorinated organic building block of significant interest in advanced chemical synthesis. Its value lies in its unique molecular architecture, which combines a reactive acyl fluoride group with halogenated and fluorinated aryl substituents, making it a versatile precursor for complex molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly those targeting CNS disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and pesticides, where the trifluoromethyl and fluorine groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic cores used in electronic display technologies and organic light-emitting diodes.
• Polymer Modification Agent: Employed to introduce fluorinated phenyl groups into polymer backbones to alter surface properties, thermal stability, and chemical resistance.
• Cross-Coupling Reactions: Acts as an electrophilic partner in palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Fluorination Reagent Research: Investigated as a potential reagent or precursor for new fluorination methodologies in organic chemistry.

Basic Information

Product Name	2-Chloro-2-Fluoro-2-[4-(Trifluoromethyl)Phenyl]Acetyl Fluoride
CAS No.	914637-11-9
Molecular Formula	C9H4ClF5O
Molecular Weight	258.57 g/mol
Synonyms	2-Chloro-2-fluoro-2-[4-(trifluoromethyl)phenyl]acetyl fluoride; α-Chloro-α-fluoro-4-(trifluoromethyl)benzeneacetyl fluoride; 4-(Trifluoromethyl)phenacyl chloride difluoride; [4-(Trifluoromethyl)phenyl](chloro)(fluoro)acetyl fluoride; 2-Chloro-2-fluoro-1-[4-(trifluoromethyl)phenyl]ethan-1-one fluoride
EINECS	Contact for details

Quality Control

Our 2-Chloro-2-Fluoro-2-[4-(Trifluoromethyl)Phenyl]Acetyl Fluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. For custom synthesis or specific purity requirements (e.g., >98%, >99%), please contact our technical sales team to discuss your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.