Description

4-Bromo-3-(Trifluoromethyl)Benzoyl Chloride is a high-value aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both bromo and trifluoromethyl substituents, makes it an indispensable reagent for introducing specific functional groups and enhancing the lipophilicity and metabolic stability of target molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used to construct advanced herbicides, fungicides, and insecticides where the trifluoromethyl group confers improved biological activity and environmental persistence.
• Liquid Crystal & OLED Material Production: Serves as a building block for creating specialized aromatic cores in electronic display and lighting materials.
• Polymer Chemistry: Employed as a monomer or modifier in the production of high-performance polymers and specialty polyamides.
• Cross-Coupling Reactions: The bromine atom makes it a suitable substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination for carbon-carbon and carbon-heteroatom bond formation.
• Peptide Mimetics & Bioconjugation: The reactive acid chloride group is utilized for acylation reactions to create peptide analogs or for labeling biomolecules.

Basic Information

Product Name	4-Bromo-3-(Trifluoromethyl)Benzoyl Chloride
CAS No.	914636-26-3
Molecular Formula	C8H3BrClF3O
Molecular Weight	287.46 g/mol
Synonyms	4-Bromo-3-(trifluoromethyl)benzoyl chloride; 4-Bromo-alpha,alpha,α-trifluoro-m-toluoyl chloride; 2-Bromo-5-(chlorocarbonyl)benzotrifluoride; 3-Trifluoromethyl-4-bromobenzoyl chloride; m-Trifluoromethyl-p-bromobenzoyl chloride; Benzoyl chloride, 4-bromo-3-(trifluoromethyl)-; 4-Bromo-3-trifluoromethylbenzoyl chloride
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-(Trifluoromethyl)Benzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. We provide detailed Certificates of Analysis (COA) with every shipment, documenting identity, assay, and impurity profiles. Our production adheres to cGMP guidelines where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.