Description

7'-Oh-n-Trityl Morpholino Thymine is a sophisticated, high-purity nucleoside phosphoramidite derivative, specifically designed for solid-phase oligonucleotide synthesis. This compound is a critical building block for the precise assembly of morpholino oligomers, which are valued for their exceptional stability and specificity in genetic research and therapeutic development. It is essential for researchers and manufacturers in the fields of antisense therapeutics, molecular biology diagnostics, and advanced genetic engineering, where reliable, high-quality synthetic intermediates are paramount for successful outcomes.

Application

• Synthesis of Morpholino Oligomers (PMOs): As a key phosphoramidite monomer for the automated solid-phase synthesis of phosphorodiamidate morpholino oligomers, used in gene silencing and splice-switching applications.
• Antisense Therapeutic Development: A crucial raw material in the research and production of investigational antisense drugs targeting genetic disorders and viral infections.
• Molecular Biology Research: Used to create custom probes and primers with enhanced nuclease resistance for in situ hybridization and other diagnostic assays.
• Genetic Functional Analysis: Enables the production of specific morpholino sequences to knock down gene expression in model organisms like zebrafish for developmental biology studies.
• Contract Manufacturing & CDMO: Supplied to pharmaceutical development and manufacturing organizations (CDMOs) for GMP-grade production of therapeutic oligonucleotides.
• Academic & Institutional Research: Provides a reliable, high-purity reagent for university labs and research institutes exploring novel oligonucleotide chemistries and applications.

Basic Information

Product Name	7'-Oh-n-Trityl Morpholino Thymine
CAS No.	914361-76-5
Molecular Formula	C33H35N3O6
Molecular Weight	569.65 g/mol
Synonyms	7'-Hydroxy-N-trityl morpholino thymine; 5-Methyl-1-[2-(4-tritylmorpholin-2-yl)ethoxy]pyrimidine-2,4-dione; Morpholino Thymine Phosphoramidite (Trityl-protected); PMO Monomer (Thymine); N-Trityl-2'-O-morpholinothymidine derivative; Oligonucleotide Synthesis Building Block; Antisense Monomer; Gene Tools monomer analog
EINECS	Contact for details

Quality Control

Every batch of 7'-Oh-n-Trityl Morpholino Thymine is manufactured and tested under strict quality systems to ensure it meets the exacting standards required for oligonucleotide synthesis. Our rigorous quality testing includes advanced chromatographic and spectroscopic methods to guarantee identity, purity, and performance. A comprehensive Certificate of Analysis (COA) detailing purity, moisture content, and solvent residues is provided with each shipment. We support development under ISO 9001 guidelines and can discuss custom synthesis aligned with cGMP principles for therapeutic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment or under an inert atmosphere to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.